NR4A1 destabilizes TNF mRNA in microglia and modulates stroke outcomes

Microglia play a dual role in stroke depending on their pro-inflammatory and anti-inflammatory polarization. A study in PLOS Biology identifies a new mechanism, through which the transcription factor NR4A1 negatively regulates TNF expression in microglia.

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	PLoS biology 2023-07, Vol.21 (7), p.e3002226-e3002226
1. Verfasser:	Yao, Yao
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Atherosclerosis Biology and Life Sciences Brain Cytokines Cytoplasm Disease Hypotheses Identification and classification Inflammation Ischemia Medicine and Health Sciences Messenger RNA Microglia Morphology Primer Properties Research and Analysis Methods Stroke (Disease) Transcription factors Tumor necrosis factor-TNF
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Microglia play a dual role in stroke depending on their pro-inflammatory and anti-inflammatory polarization. A study in PLOS Biology identifies a new mechanism, through which the transcription factor NR4A1 negatively regulates TNF expression in microglia.
ISSN:	1545-7885 1544-9173 1545-7885
DOI:	10.1371/journal.pbio.3002226