Patterns of brain atrophy in recently-diagnosed relapsing-remitting multiple sclerosis

Recurrent neuroinflammation in relapsing-remitting MS (RRMS) is thought to lead to neurodegeneration, resulting in progressive disability. Repeated magnetic resonance imaging (MRI) of the brain provides non-invasive measures of atrophy over time, a key marker of neurodegeneration. This study investi...

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Veröffentlicht in:	PloS one 2023-07, Vol.18 (7), p.e0288967
Hauptverfasser:	Meijboom, Rozanna, York, Elizabeth N, Kampaite, Agniete, Harris, Mathew A, White, Nicole, Valdés Hernández, Maria Del C, Thrippleton, Michael J, MacDougall, N J J, Connick, Peter, Hunt, David P J, Chandran, Siddharthan, Waldman, Adam D
Format:	Artikel
Sprache:	eng
Schlagworte:	Amygdala Analysis Atrophy Atrophy - pathology Basal ganglia Biology and Life Sciences Biomarkers Brain Brain - diagnostic imaging Brain - pathology Brain research Brain stem Central Nervous System Diseases - pathology Cerebellum Cingulum Clinical trials Clusters Complications and side effects Cortex (motor) Decision making Development and progression Diagnosis Diagnostic imaging Diencephalon Frontal lobe Ganglia Gray Matter - diagnostic imaging Gray Matter - pathology Humans Inflammation Magnetic resonance Magnetic resonance imaging Magnetic Resonance Imaging - methods Medical imaging Medical imaging equipment Medical research Medicine and Health Sciences Medicine, Experimental Morphometry Multiple sclerosis Multiple Sclerosis - pathology Multiple Sclerosis, Relapsing-Remitting - diagnostic imaging Multiple Sclerosis, Relapsing-Remitting - pathology Neurodegeneration Neuroimaging Nucleus accumbens Occipital lobe Research and Analysis Methods Statistical analysis Substantia alba Substantia grisea Temporal cortex Temporal lobe Thalamus
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Beschreibung
Zusammenfassung:	Recurrent neuroinflammation in relapsing-remitting MS (RRMS) is thought to lead to neurodegeneration, resulting in progressive disability. Repeated magnetic resonance imaging (MRI) of the brain provides non-invasive measures of atrophy over time, a key marker of neurodegeneration. This study investigates regional neurodegeneration of the brain in recently-diagnosed RRMS using volumetry and voxel-based morphometry (VBM). RRMS patients (N = 354) underwent 3T structural MRI
ISSN:	1932-6203 1932-6203
DOI:	10.1371/journal.pone.0288967