The efficacy and safety of 0.01% atropine alone or combined with orthokeratology for children with myopia: A meta-analysis

To evaluate the efficacy and safety of 0.01% atropine alone and in combination with orthokeratology for myopia control using a meta-analysis. PubMed, Cochrane Library, and EMBASE were searched. We included eligible randomized controlled trials (RCTs), non-RCTs, and retrospective cohort studies, publ...

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Veröffentlicht in:PloS one 2023-07, Vol.18 (7), p.e0282286-e0282286
Hauptverfasser: Wang, Zengying, Wang, Pengfei, Jiang, Bohua, Meng, Yifei, Qie, Sufang, Yan, Zhipeng
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Sprache:eng
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Zusammenfassung:To evaluate the efficacy and safety of 0.01% atropine alone and in combination with orthokeratology for myopia control using a meta-analysis. PubMed, Cochrane Library, and EMBASE were searched. We included eligible randomized controlled trials (RCTs), non-RCTs, and retrospective cohort studies, published up to August 1, 2022. We calculated the weighted mean difference (WMD) and 95% confidence interval (CI) for all outcomes and plotted them in forest plots. Fourteen studies were included; 4 and 11 in the 0.01% atropine monotherapy and atropine-orthokeratology (AOK) groups, respectively. Compared with orthokeratology (OK) alone, 0.01% atropine alone had similar effects on slowing the axial elongation (WMD: -0.00 mm; 95% CI: -0.05-0.04, p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0282286