Do sex hormones confound or mediate the effect of chronotype on breast and prostate cancer? A Mendelian randomization study

Morning-preference chronotype has been found to be protective against breast and prostate cancer. Sex hormones have been implicated in relation to chronotype and the development of both cancers. This study aimed to assess whether sex hormones confound or mediate the effect of chronotype on breast an...

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Veröffentlicht in:	PLoS genetics 2022-01, Vol.18 (1), p.e1009887-e1009887
Hauptverfasser:	Hayes, Bryony L, Robinson, Timothy, Kar, Siddhartha, Ruth, Katherine S, Tsilidis, Konstantinos K, Frayling, Timothy, Murray, Anna, Martin, Richard M, Lawlor, Deborah A, Richmond, Rebecca C
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Bioavailability Biobanks Biology and Life Sciences Breast cancer Breast Neoplasms - genetics Chronobiology Phenomena Circadian rhythm Cohort analysis Databases, Genetic Female Gender differences Genetic diversity Genetic Predisposition to Disease Genetic variance Genome-wide association studies Genome-Wide Association Study Genomes Globulins Gonadal Steroid Hormones - metabolism Hormone replacement therapy Hormones, Sex Humans Intermediates Male Males Medical screening Medicine and Health Sciences Mendelian Randomization Analysis - methods Physiological aspects Polymorphism, Single Nucleotide Prostate cancer Prostatic Neoplasms - genetics Risk Factors Sex hormones Sleep Testosterone Womens health
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Zusammenfassung:	Morning-preference chronotype has been found to be protective against breast and prostate cancer. Sex hormones have been implicated in relation to chronotype and the development of both cancers. This study aimed to assess whether sex hormones confound or mediate the effect of chronotype on breast and prostate cancer using a Mendelian Randomization (MR) framework. Genetic variants associated with chronotype and sex hormones (total testosterone, bioavailable testosterone, sex hormone binding globulin, and oestradiol) (p
ISSN:	1553-7404 1553-7390 1553-7404
DOI:	10.1371/journal.pgen.1009887