High baseline body mass index predicts recovery of CD4+ T lymphocytes for HIV/AIDS patients receiving long-term antiviral therapy

The relationship between baseline BMI and CD4+ T cells during follow-up in HIV patients in China requires further evaluation. We conducted a retrospective cohort study based on adult AIDS patients who underwent or received antiretroviral therapy from 2003 to 2019 in Guangxi, China. BMI was divided i...

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Veröffentlicht in:	PloS one 2022-12, Vol.17 (12), p.e0279731
Hauptverfasser:	Zhu, Jiawen, Huang, Haimei, Wang, Min, Zhang, Yun, Mo, Jinli, Tian, Weiyi, Tan, Sumin, Jiang, Li, Meng, Zhihao, Qin, Shanfang, Ning, Chuanyi
Format:	Artikel
Sprache:	eng
Schlagworte:	Acquired immune deficiency syndrome Acquired Immunodeficiency Syndrome - drug therapy Adult Age AIDS Antiretroviral agents Antiretroviral drugs Antiretroviral therapy Antiretroviral Therapy, Highly Active Antiviral agents Antiviral Agents - therapeutic use Antiviral drugs Bacterial infections Biology and Life Sciences Body mass Body Mass Index Body size Care and treatment CD4 antigen CD4 Lymphocyte Count CD4-Positive T-Lymphocytes Cell number China Cohort analysis Complications and side effects Data collection Drug therapy Ethics Health aspects Highly active antiretroviral therapy HIV HIV (Viruses) HIV Infections - drug therapy HIV patients Human immunodeficiency virus Humans Immune reconstitution Infections Lymphocytes Lymphocytes T Medical research Medicine and Health Sciences Medicine, Experimental Mortality Obesity Overweight Patient outcomes Regression analysis Retrospective Studies Risk analysis Risk factors Statistical analysis T cells Tuberculosis Underweight Variables Viral Load
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Zusammenfassung:	The relationship between baseline BMI and CD4+ T cells during follow-up in HIV patients in China requires further evaluation. We conducted a retrospective cohort study based on adult AIDS patients who underwent or received antiretroviral therapy from 2003 to 2019 in Guangxi, China. BMI was divided into categories and compared, and after adjusting for BMI being related to the change in CD4 lymphocyte count, with normal weight as the reference group, the BMI before treatment was positively correlated with the changes in CD4+ T cells at different time periods. Among them, obese patients had significant CD4+ cell gain. In patients with pretreatment CD4+ T lymphocyte counts
ISSN:	1932-6203 1932-6203
DOI:	10.1371/journal.pone.0279731