Long-term diagnosis-specific sickness absence, disability pension, and healthcare use in 1305 young adult childhood cancer survivors and in 6430 references; a Swedish ten-year prospective cohort study

Childhood cancer survivors (CCS) are at high risk of chronic health conditions. We aimed to explore young adult CCS' and matched references' future diagnoses-specific healthcare use, sickness absence (SA), and disability pension (DP). We performed a prospective cohort study with microdata from seven nationwide Swedish registers. We included 1305 young adult CCS born 1983-1988 and living in Sweden in 2008 and 6430 matched references and followed them for ten years (2009-2018) regarding mean annual specialized outpatient visits, inpatient days, and SA (spells >14 days) and/or DP (SADP) days, overall and by eight diagnostic groups. Risk factors for >90 SADP days in 2018 were explored as odds ratios (OR) with 95% confidence intervals (CI) by adjusted logistic regression. Approximately 80% of CCS and 90% of references did not have SADP in the ten-year follow-up. Mean SADP days/year was higher among CCS (40-50 days/year), particularly in CNS tumor survivors (76-83 days/year), compared to references (12-18 days/year). Most SADP days were DP days. CCS had more mean outpatient visits (1.6-1.8 visits/year) and inpatient days (0.8-1.7 days/year) than references (0.8-1.2 visits/year and 0.6-0.75 days/year, respectively). The main healthcare use and SADP diagnoses were neoplasms and psychiatric disorders among all CCS, along with nervous system and endocrine conditions among CNS tumor survivors. The risk of SADP >90 days in 2018 was higher among female compared to male CCS (OR = 2.34, 95% CI 1.67-3.32), those with elementary schooling compared to high school/university education (OR = 6.52, 95% CI 4.49-9.49), and survivors of CNS tumors compared to other malignancies (OR hematological versus CNS = 2.88, 95% CI 1.95-4.28; OR hematological versus non-CNS solid tumors = 0.71, 95% CI 0.45-1.09). Most CCS did not have SADP as young adults; nevertheless, their risk of SADP was higher than among matched references. CNS tumor survivors were at particularly high risk of SADP.