Overall survival of triple negative breast cancer in French Caribbean women

To describe survival according to prognostic factors of women with breast cancer in French overseas territory (Martinique) during 2008–2017. We performed a Cox model for prognostic factors for OS in breast cancer patients. The cut-off date for the analysis was 13/10/2018. The main factors were demog...

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Veröffentlicht in:PloS one 2022-08, Vol.17 (8), p.e0271966-e0271966
Hauptverfasser: Beaubrun-Renard, Murielle Murielle, Veronique-Baudin, Jacqueline, Macni, Jonathan, Ulric-Gervaise, Stephen, Almont, Thierry, Aline-Fardin, Aude, Grossat, Nathalie, Furtos, Cristina, Escarmant, Patrick, Vinh-Hung, Vincent, Bougas, Stefanos, Cabie, André, Joachim, Clarisse
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Sprache:eng
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Zusammenfassung:To describe survival according to prognostic factors of women with breast cancer in French overseas territory (Martinique) during 2008–2017. We performed a Cox model for prognostic factors for OS in breast cancer patients. The cut-off date for the analysis was 13/10/2018. The main factors were demographic data, stage, hormone receptors (HR) status and HER2 status. Curves were compared with the log rank test to select candidate variables for the multivariate analysis. We included 1,708 patients; median age at diagnosis was 57 years. Triple negative breast cancer (TNBC) accounted for 20.9% (n = 332). Among the patients, 72.3% (n = 1015) had localised or local spread cancer. One-year OS was 95.2% and was 80.1% at 5 years. In TNBC, 1-year-survival was 90.4%, which fell to 70.1% at 5 years. Patients with metastatic disease at diagnosis had 1-year-survival of 74.5%, and 20.1% at 5 years. Multivariate analysis by Cox regression identified 4 factors significantly associated with an increased risk of death: metastatic disease at diagnosis (hazard ratio (HR) = 15, p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0271966