Increase in short telomeres during the third trimester in human placenta

An increase in telomere shortening in gestational tissues has been proposed as a mechanism involved in the timing for the initiation of parturition. An increase in very short telomeres with increasing gestational age has been observed in mice; this study sought to explore this phenomenon in human pr...

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Veröffentlicht in:PloS one 2022-07, Vol.17 (7), p.e0271415-e0271415
Hauptverfasser: Edelson, Paula K, Sawyer, Michala R, Gray, Kathryn J, Cantonwine, David E, McElrath, Thomas F, Phillippe, Mark
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Sprache:eng
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Zusammenfassung:An increase in telomere shortening in gestational tissues has been proposed as a mechanism involved in the timing for the initiation of parturition. An increase in very short telomeres with increasing gestational age has been observed in mice; this study sought to explore this phenomenon in human pregnancies. Specifically, this study addressed the hypothesis that prior to labor, the quantity of very short telomeres (
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0271415