A cytokine panel and procalcitonin in COVID-19, a comparison between intensive care and non-intensive care patients

Procalcitonin (PCT) is an acute-phase reactant with concentrations ≥0.5 μg/L indicative of possible bacterial infection in patients with SARS-CoV-2 infection (COVID-19). Some with severe COVID-19 develop cytokine storm secondary to virally driven hyper-inflammation. However, increased pro-inflammato...

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Veröffentlicht in:PloS one 2022-05, Vol.17 (5), p.e0266652-e0266652
Hauptverfasser: Mazaheri, Tina, Ranasinghe, Ruvini, Al-Hasani, Wiaam, Luxton, James, Kearney, Jessica, Manning, Allison, Dimitriadis, Georgios K, Mare, Tracey, Vincent, Royce P
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Sprache:eng
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Zusammenfassung:Procalcitonin (PCT) is an acute-phase reactant with concentrations ≥0.5 μg/L indicative of possible bacterial infection in patients with SARS-CoV-2 infection (COVID-19). Some with severe COVID-19 develop cytokine storm secondary to virally driven hyper-inflammation. However, increased pro-inflammatory cytokines are also seen in bacterial sepsis. This study aimed to assess the clinical utility of a cytokine panel in the assessment of COVID-19 with bacterial superinfections along with PCT and C-reactive protein (CRP). The retrospective analysis included serum cytokines (interleukins; IL-1β, IL-6, IL-8 and tumour necrosis factor (TNFα)) measured using Ella™ (Bio-Techne, Oxford, UK) and PCT measured by Roche Cobas (Burgess Hill, UK) in patients admitted with COVID-19 between March 2020 and January 2021. Patients enrolled into COVID-19 clinical trials, treated with Remdesivir/IL-6 inhibitors were excluded. The cytokine data was compared between intensive care unit (ICU) patients, age matched non-ICU patients and healthy volunteers as well as ICU patients with high and normal PCT (≥0.5 vs.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0266652