A common evolutionary origin reveals fundamental principles of protein insertases

Membrane proteins require protein machineries to insert their hydrophobic transmembrane domains (TMDs) into the lipid bilayer. A functional analysis of protein insertases in this issue of PLOS Biology reveals that the fundamental mechanism of membrane protein insertion is universally conserved.

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	PLoS biology 2022-03, Vol.20 (3), p.e3001558-e3001558
Hauptverfasser:	Vögtle, F-Nora, Koch, Hans-Georg, Meisinger, Chris
Format:	Artikel
Sprache:	eng
Schlagworte:	Binding sites Biology and Life Sciences E coli Endoplasmic reticulum Evolution Functional analysis Genetic aspects Gram-positive bacteria Health aspects Hydrophobic and Hydrophilic Interactions Hydrophobicity Hypotheses Lipid bilayers Lipid Bilayers - chemistry Lipids Membrane proteins Membrane Proteins - genetics Membrane Proteins - metabolism Membranes Mitochondria Physiological aspects Primer Principles Proteins Transmembrane domains
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Membrane proteins require protein machineries to insert their hydrophobic transmembrane domains (TMDs) into the lipid bilayer. A functional analysis of protein insertases in this issue of PLOS Biology reveals that the fundamental mechanism of membrane protein insertion is universally conserved.
ISSN:	1545-7885 1544-9173 1545-7885
DOI:	10.1371/journal.pbio.3001558