Expression characteristics of polymeric immunoglobulin receptor in Bactrian camel (Camelus bactrianus) lungs

Polymeric immunoglobulin receptor (pIgR), the transmembrane transporter of polymeric immunoglobulin A and M, has multiple immune functions. To explore the characteristics of pIgR expression in Bactrian camel lungs, twelve healthy adult (2-7 years old) Bactrian camels were systematically studied. The...

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Veröffentlicht in:PloS one 2022-03, Vol.17 (3), p.e0264815-e0264815
Hauptverfasser: He, Wan-Hong, Zhang, Wang-Dong, Cheng, Cui-Cui, Lu, Jia, Liu, Lei, Chen, Zhi-Hua, Wang, Wen-Hui
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Sprache:eng
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Zusammenfassung:Polymeric immunoglobulin receptor (pIgR), the transmembrane transporter of polymeric immunoglobulin A and M, has multiple immune functions. To explore the characteristics of pIgR expression in Bactrian camel lungs, twelve healthy adult (2-7 years old) Bactrian camels were systematically studied. The results showed that pIgR was mainly expressed in the cytoplasm and membrane of ciliated cells, as well as in the cytoplasm and membrane of basal cells, serous cells of bronchial glands, club cells and alveolar type 2 cells in Bactrian camel lungs. Specially, as the bronchial branches extended, the pIgR expression level in ciliated cells significantly declined (p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0264815