Neonatal brain injury influences structural connectivity and childhood functional outcomes

Neonatal brain injury influences structural connectivity and childhood functional outcomes

Neonatal brain injury may impact brain development and lead to lifelong functional impairments. Hypoxic-ischemic encephalopathy (HIE) and congenital heart disease (CHD) are two common causes of neonatal brain injury differing in timing and mechanism. Maturation of whole-brain neural networks can be...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:PloS one 2022-01, Vol.17 (1), p.e0262310-e0262310
Hauptverfasser: Ramirez, Alice, Peyvandi, Shabnam, Cox, Stephany, Gano, Dawn, Xu, Duan, Tymofiyeva, Olga, McQuillen, Patrick S
Format: Artikel
Sprache:eng
Schlagworte:
Apgar score
Biology and Life Sciences
Brain
Brain - physiopathology
Brain damage
Brain Injuries - physiopathology
Brain injury
Brain research
Cardiovascular disease
Cardiovascular diseases
Central nervous system diseases
Child
Child development
Childhood
Children
Cognitive ability
Computer and Information Sciences
Congenital diseases
Connectome - methods
Coronary artery disease
Diffusion Magnetic Resonance Imaging - methods
Diseases
Encephalopathy
Female
Graph theory
Head injuries
Health aspects
Heart
Heart Defects, Congenital - physiopathology
Heart diseases
Humans
Hypoxia
Hypoxia-Ischemia, Brain - physiopathology
Infant, Newborn
Infants (Newborn)
Injuries
Ischemia
Language
Longitudinal Studies
Magnetic resonance
Magnetic resonance imaging
Magnetic Resonance Imaging - methods
Male
Medicine and Health Sciences
Modularity
Neonates
Nerve Net - physiopathology
Neural circuitry
Neural networks
Neural Pathways - physiopathology
Neuroimaging
Newborn babies
Pediatric research
Pediatrics
Physiology
Prospective Studies
Regional development
Research and Analysis Methods
Risk factors
Social Sciences
Surgery
Traumatic brain injury
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Neonatal brain injury may impact brain development and lead to lifelong functional impairments. Hypoxic-ischemic encephalopathy (HIE) and congenital heart disease (CHD) are two common causes of neonatal brain injury differing in timing and mechanism. Maturation of whole-brain neural networks can be quantified during development using diffusion magnetic resonance imaging (dMRI) in combination with graph theory metrics. DMRI of 35 subjects with CHD and 62 subjects with HIE were compared to understand differences in the effects of HIE and CHD on the development of network topological parameters and functional outcomes. CHD newborns had worse 12-18 month language (P
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0262310