Correlation of breast cancer microcirculation construction with tumor stem cells (CSCs) and epithelial-mesenchymal transition (EMT) based on contrast-enhanced ultrasound (CEUS)

Correlation of breast cancer microcirculation construction with tumor stem cells (CSCs) and epithelial-mesenchymal transition (EMT) based on contrast-enhanced ultrasound (CEUS)

This study is to explore the correlation between the contrast-enhanced ultrasound (CEUS) characteristics of breast cancer and the epithelial-mesenchyme transformation (EMT). Totally 119 patients of breast cancer underwent CEUS. Tissues in the active area were collected and subjected to the immunohis...

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Veröffentlicht in:PloS one 2021-12, Vol.16 (12), p.e0261138-e0261138
Hauptverfasser: Leng, Xiaoling, Huang, Guofu, Li, Siyi, Yao, Miaomiao, Ding, Jianbing, Ma, Fucheng
Format: Artikel
Sprache:eng
Schlagworte:
Biology and Life Sciences
Biomarkers
Biomarkers, Tumor - metabolism
Biopsy
Breast cancer
Breast Neoplasms - diagnostic imaging
Breast Neoplasms - metabolism
Breast Neoplasms - pathology
Cancer therapies
CD44 antigen
Contrast Media - metabolism
Correlation
Correlation analysis
Cytoplasm
E-cadherin
Epithelial-Mesenchymal Transition
Estrogen receptors
Estrogens
Female
Humans
Lymph nodes
Medical prognosis
Medicine and Health Sciences
Mesenchyme
Metastases
Metastasis
Microcirculation
Middle Aged
Monoclonal antibodies
mRNA
N-Cadherin
Neoplastic Stem Cells - metabolism
Neoplastic Stem Cells - pathology
Patients
Perfusion
Phenotypes
Prognosis
Stem cells
Tissues
Tumors
Ultrasonic imaging
Ultrasonography, Mammary - methods
Ultrasound
Vimentin
β-Catenin
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Zusammenfassung:This study is to explore the correlation between the contrast-enhanced ultrasound (CEUS) characteristics of breast cancer and the epithelial-mesenchyme transformation (EMT). Totally 119 patients of breast cancer underwent CEUS. Tissues in the active area were collected and subjected to the immunohistochemical detection, PT-PCR and Western blot. Correlation analysis was conducted between the clinical pathological parameters and the CEUS indicators. The expression levels of CD44, N-cadherin, and β-catenin in breast cancer tissues were higher than those in adjacent tissues (P
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0261138