It takes two to tango: Concerted protein translation and degradation necessary for synaptic scaling

It takes two to tango: Concerted protein translation and degradation necessary for synaptic scaling

Synaptic scaling allows neurons to adjust synaptic strength in response to chronic alterations in neuronal activity. A new study in PLOS Biology identifies a pathway that synergizes protein synthesis and degradation with remodeling of the microRNA (miRNA)-induced silencing complex (miRISC) to mediat...

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Veröffentlicht in:PLoS biology 2021-11, Vol.19 (11), p.e3001448-e3001448
Hauptverfasser: Carvalho, Ana Luisa, Fernandes, Dominique
Format: Artikel
Sprache:eng
Schlagworte:
Biology and Life Sciences
Degradation
Gene expression
Hyperactivity
MicroRNAs
MicroRNAs - metabolism
miRNA
Neurons
Neurons - metabolism
Primer
Protein Biosynthesis
Protein synthesis
Proteins
Research and Analysis Methods
Ribonucleic acid
RNA
Scaling
Synaptic strength
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Zusammenfassung:Synaptic scaling allows neurons to adjust synaptic strength in response to chronic alterations in neuronal activity. A new study in PLOS Biology identifies a pathway that synergizes protein synthesis and degradation with remodeling of the microRNA (miRNA)-induced silencing complex (miRISC) to mediate synaptic scaling.
ISSN:1545-7885
1544-9173
1545-7885
DOI:10.1371/journal.pbio.3001448