Prevalence, incidence and predictors of renal impairment in persons with HIV receiving protease-inhibitors in rural Tanzania

Ritonavir-boosted protease inhibitors (bPI) in people living with HIV (PLWH) have been associated with renal impairment. Limited data are available from rural sub-Saharan Africa. Using data from the Kilombero and Ulanga Antiretroviral Cohort Study (KIULARCO) in rural Tanzania from 2005-01/2020, we a...

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Veröffentlicht in:	PloS one 2021-12, Vol.16 (12), p.e0261367-e0261367
Hauptverfasser:	Mapesi, Herry, Okuma, James, Franzeck, Fabian, Wilson, Herieth Ismael, Senkoro, Elizabeth, Byakuzana, Theonestina, Ndege, Robert, Vanobberghen, Fiona, Glass, Tracy Renée, Battegay, Manuel, Weisser, Maja, Paris, Daniel Henry
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Age Anti-HIV Agents - therapeutic use Anti-Retroviral Agents - therapeutic use Antiretroviral agents Antiretroviral drugs Antiretroviral therapy Biology and Life Sciences Body mass Body mass index Body size Care and treatment Chronic illnesses Cohort Studies Complications and side effects Creatinine Epidemiology Female Glomerular filtration rate Glomerular Filtration Rate - physiology Highly active antiretroviral therapy HIV HIV infection HIV Infections - complications HIV Infections - drug therapy HIV Infections - genetics HIV Protease Inhibitors - adverse effects HIV Protease Inhibitors - therapeutic use HIV-1 - metabolism HIV-1 - pathogenicity Hospitals Human immunodeficiency virus Humans Hypertension Immunology Impairment Incidence Infectious diseases Kidney diseases Laboratories Male Medicine and Health Sciences Middle Aged Mortality Patient outcomes Prevalence Prospective Studies Protease Protease inhibitors Proteinase inhibitors Public health Regression analysis Regression models Renal function Renal Insufficiency - etiology Renal Insufficiency - virology Risk analysis Risk Factors Ritonavir Rural Population Tanzania - epidemiology Tuberculosis
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Zusammenfassung:	Ritonavir-boosted protease inhibitors (bPI) in people living with HIV (PLWH) have been associated with renal impairment. Limited data are available from rural sub-Saharan Africa. Using data from the Kilombero and Ulanga Antiretroviral Cohort Study (KIULARCO) in rural Tanzania from 2005-01/2020, we assessed the prevalence of renal impairment (estimated glomerular filtration rate
ISSN:	1932-6203 1932-6203
DOI:	10.1371/journal.pone.0261367