Immunological exhaustion: How to make a disparate concept operational?

In this essay, we show that 3 distinct approaches to immunological exhaustion coexist and that they only partially overlap, generating potential misunderstandings. Exploring cases ranging from viral infections to cancer, we propose that it is crucial, for experimental and therapeutic purposes, to cl...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	PLoS pathogens 2021-09, Vol.17 (9), p.e1009892-e1009892
Hauptverfasser:	Kaminski, Hannah, Lemoine, Maël, Pradeu, Thomas
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigens Apoptosis Biology and Life Sciences Cancer Cellular control mechanisms Coronaviruses COVID-19 Cytokines Cytotoxicity Development and progression Health aspects Hepatitis History, Philosophy and Sociology of Sciences Humanities and Social Sciences Immune response Immunological research Immunology Infection Infections Life Sciences Lymphocytes Medicine and Health Sciences Regulation Review Therapeutic applications Viral infections
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	In this essay, we show that 3 distinct approaches to immunological exhaustion coexist and that they only partially overlap, generating potential misunderstandings. Exploring cases ranging from viral infections to cancer, we propose that it is crucial, for experimental and therapeutic purposes, to clarify these approaches and their interconnections so as to make the concept of exhaustion genuinely operational.
ISSN:	1553-7374 1553-7366 1553-7374
DOI:	10.1371/journal.ppat.1009892