Pathophysiology and inflammatory biomarkers of sulfur mustard-induced corneal injury in rabbits

Sulfur mustard (SM) is a cytotoxic, vesicating, chemical warfare agent, first used in 1917; corneas are particularly vulnerable to SM exposure. They may develop inflammation, ulceration, neovascularization (NV), impaired vision, and partial/complete blindness depending upon the concentration of SM,...

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Veröffentlicht in:	PloS one 2021-10, Vol.16 (10), p.e0258503
Hauptverfasser:	Goswami, Dinesh G, Mishra, Neha, Kant, Rama, Agarwal, Chapla, Croutch, Claire R, Enzenauer, Robert W, Petrash, Mark J, Tewari-Singh, Neera, Agarwal, Rajesh
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Animals Biocompatibility Biological markers Biology and Life Sciences Biomarkers Biomarkers - metabolism Blindness Blood Blood vessels Blood Vessels - cytology Blood Vessels - drug effects Blood Vessels - metabolism Cell Survival - drug effects Chemical warfare Chemical Warfare Agents - toxicity Cornea Cornea - drug effects Cornea - metabolism Cornea - pathology Corneal diseases Corneal Injuries - etiology Corneal Injuries - metabolism Corneal Keratocytes - cytology Corneal Keratocytes - drug effects Corneal Keratocytes - metabolism Cyclooxygenase 2 - metabolism Cyclooxygenase-2 Cytokines Cytotoxicity Diagnosis Edema Exposure Eye (anatomy) Gelatinase B Growth factors Health aspects In vivo methods and tests Inflammation Interleukin 8 Interleukin-8 - metabolism Matrix metalloproteinase Matrix Metalloproteinase 9 - metabolism Matrix metalloproteinases Medicine and Health Sciences Metalloproteinase Mustard gas Mustard Gas - toxicity Opacity Ophthalmology Pathophysiology Pharmaceutical sciences Physical Sciences Rabbits Research and Analysis Methods Sulfur Therapeutic applications Toxicity Vascular endothelial growth factor Vascularization Wound healing
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Beschreibung
Zusammenfassung:	Sulfur mustard (SM) is a cytotoxic, vesicating, chemical warfare agent, first used in 1917; corneas are particularly vulnerable to SM exposure. They may develop inflammation, ulceration, neovascularization (NV), impaired vision, and partial/complete blindness depending upon the concentration of SM, exposure duration, and bio-physiological conditions of the eyes. Comprehensive in vivo studies have established ocular structural alterations, opacity, NV, and inflammation upon short durations (
ISSN:	1932-6203 1932-6203
DOI:	10.1371/journal.pone.0258503