High levels of pathological jaundice in the first 24 hours and neonatal hyperbilirubinaemia in an epidemiological cohort study on the Thailand-Myanmar border

Population risks for neonatal hyperbilirubinaemia (NH) vary. Knowledge of local risks permits interventions that may reduce the proportion becoming severe. Between January 2015 and May 2016, in a resource-limited setting on the Thailand-Myanmar border, neonates from 28 weeks' gestation were enr...

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Veröffentlicht in:	PloS one 2021-10, Vol.16 (10), p.e0258127-e0258127
Hauptverfasser:	Thielemans, Laurence, Peerawaranun, Pimnara, Mukaka, Mavuto, Paw, Moo Kho, Wiladphaingern, Jacher, Landier, Jordi, Bancone, Germana, Proux, Stephane, Elsinga, Henrike, Trip-Hoving, Margreet, Hanboonkunupakarn, Borimas, Htoo, Tha Ler, Wah, Thaw Shee, Beau, Candy, Nosten, Francois, McGready, Rose, Carrara, Verena I
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Attended births Bilirubin Bilirubin - blood Biology and Life Sciences Cohort analysis Cohort Studies Diagnosis Distribution Encephalopathy Epidemiologic Studies Epidemiology Ethnicity - genetics Female Genotype Genotyping Gestational age Glucosephosphate dehydrogenase Glucosephosphate Dehydrogenase Deficiency - blood Glucosephosphate Dehydrogenase Deficiency - complications Glucosephosphate Dehydrogenase Deficiency - genetics Glucosephosphate Dehydrogenase Deficiency - mortality Health aspects Health risks Humans Hyperbilirubinemia, Neonatal - blood Hyperbilirubinemia, Neonatal - genetics Hyperbilirubinemia, Neonatal - mortality Hyperbilirubinemia, Neonatal - pathology Infant, Newborn Infants (Newborn) Jaundice Kernicterus - blood Kernicterus - complications Kernicterus - genetics Kernicterus - mortality Life Sciences Light therapy Malaria Male Marginalized groups Medicine Medicine and Health Sciences Minority & ethnic groups Myanmar - epidemiology Neonates Newborn babies Pre-eclampsia Pre-Eclampsia - blood Pre-Eclampsia - genetics Pre-Eclampsia - mortality Preeclampsia Pregnancy Proportional Hazards Models Prospective Studies Refugees Resettlement Risk analysis Risk Factors Thailand - epidemiology
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Zusammenfassung:	Population risks for neonatal hyperbilirubinaemia (NH) vary. Knowledge of local risks permits interventions that may reduce the proportion becoming severe. Between January 2015 and May 2016, in a resource-limited setting on the Thailand-Myanmar border, neonates from 28 weeks' gestation were enrolled into a prospective birth cohort. Each neonate had total serum bilirubin measurements: scheduled (24, 48, 72 and 144 hours of life) and clinically indicated; and weekly follow up until 1 month of age. Risk factors for developing NH were evaluated using Cox proportional hazard mixed model. Of 1710 neonates, 22% (376) developed NH (83% preterm, 19% term). All neonates born
ISSN:	1932-6203 1932-6203
DOI:	10.1371/journal.pone.0258127