Levels of pneumococcal conjugate vaccine coverage and indirect protection against invasive pneumococcal disease and pneumonia hospitalisations in Australia: An observational study

There is limited empiric evidence on the coverage of pneumococcal conjugate vaccines (PCVs) required to generate substantial indirect protection. We investigate the association between population PCV coverage and indirect protection against invasive pneumococcal disease (IPD) and pneumonia hospitali...

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Veröffentlicht in:	PLoS medicine 2021-08, Vol.18 (8), p.e1003733-e1003733
Hauptverfasser:	Chan, Jocelyn, Gidding, Heather F, Blyth, Christopher C, Fathima, Parveen, Jayasinghe, Sanjay, McIntyre, Peter B, Moore, Hannah C, Mulholland, Kim, Nguyen, Cattram D, Andrews, Ross, Russell, Fiona M
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Age groups Biology and Life Sciences Birth Children Children & youth Disease Evaluation Medicine and Health Sciences Observational studies Pediatric research People and Places Pneumococcal vaccine Pneumonia Pneumonia in children Prevention Regression analysis Rural populations Schedules Statistics Streptococcus infections Urban populations Vaccines
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Beschreibung
Zusammenfassung:	There is limited empiric evidence on the coverage of pneumococcal conjugate vaccines (PCVs) required to generate substantial indirect protection. We investigate the association between population PCV coverage and indirect protection against invasive pneumococcal disease (IPD) and pneumonia hospitalisations among undervaccinated Australian children. Birth and vaccination records, IPD notifications, and hospitalisations were individually linked for children aged
ISSN:	1549-1676 1549-1277 1549-1676
DOI:	10.1371/journal.pmed.1003733