Differences in the characteristics and contemporary cardiac outcomes of patients with light-chain versus transthyretin cardiac amyloidosis

To compare the baseline cardiovascular characteristics of immunoglobulin light-chain (AL) and amyloid transthyretin (ATTR) cardiac amyloidosis (CA) and to investigate patients' contemporary cardiac outcomes. Single-center analysis of clinical, laboratory, echocardiographic and cardiac magnetic...

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Veröffentlicht in:PloS one 2021-08, Vol.16 (8), p.e0255487-e0255487
Hauptverfasser: Itzhaki Ben Zadok, Osnat, Vaturi, Mordehay, Vaxman, Iuliana, Iakobishvili, Zaza, Rhurman-Shahar, Noa, Kornowski, Ran, Hamdan, Ashraf
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Sprache:eng
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Zusammenfassung:To compare the baseline cardiovascular characteristics of immunoglobulin light-chain (AL) and amyloid transthyretin (ATTR) cardiac amyloidosis (CA) and to investigate patients' contemporary cardiac outcomes. Single-center analysis of clinical, laboratory, echocardiographic and cardiac magnetic resonance imaging (CMRi) characteristics of AL and ATTR-CA patients' cohort (years 2013-2020). Included were 67 CA patients of whom 31 (46%) had AL-CA and 36 (54%) had ATTR-CA. Patients with ATTR-CA versus AL-CA were older (80 (IQR 70, 85) years versus 65 (IQR 60, 71) years, respectively, p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0255487