Oxidative stress response in children undergoing cardiac surgery: Utility of the clearance of isoprostanes

Cardiac surgery (CS) in pediatric patients induces an overt oxidative stress (OS) response. Children are particularly vulnerable to OS related injury. The immaturity of their organs and antioxidant systems as well as the induction of OS in cardio-pulmonary bypass (CPB) surgery may have an important...

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Veröffentlicht in:	PloS one 2021-07, Vol.16 (7), p.e0250124
Hauptverfasser:	Hadley, Stephanie, Cañizo Vazquez, Debora, Lopez Abad, Miriam, Congiu, Stefano, Lushchencov, Dmytro, Camprubí Camprubí, Marta, Sanchez-de-Toledo, Joan
Format:	Artikel
Sprache:	eng
Schlagworte:	Anesthesia Antioxidants Arteries Biology and Life Sciences Biomarkers Blood Cardiac Surgical Procedures - adverse effects Cardiopulmonary Bypass - adverse effects Cardiovascular diseases Chemical compounds Children Clinical outcomes Coronary artery disease Creatinine Cyanosis Diagnosis Dinoprost - analogs & derivatives Dinoprost - urine EEG Female Free radicals Heart Heart Defects, Congenital - metabolism Heart Defects, Congenital - surgery Heart diseases Heart surgery Hemoglobin Hospitals Humans Independent sample Infant Infant, Newborn Infants Infrared spectra Infrared spectroscopy Isoprostanes Isoprostanes - urine Male Mechanical ventilation Medicine and Health Sciences Morbidity Near infrared radiation Near infrared spectroscopy Neonates Newborn babies Organs Oxidative Stress Oxygen Oxygen content Patients Pediatrics People and Places Physiology Seizures Surgery Transposition Urine Ventilation
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Zusammenfassung:	Cardiac surgery (CS) in pediatric patients induces an overt oxidative stress (OS) response. Children are particularly vulnerable to OS related injury. The immaturity of their organs and antioxidant systems as well as the induction of OS in cardio-pulmonary bypass (CPB) surgery may have an important impact on outcomes. The purpose of this study was to describe the OS response, measured by urinary free 8-iso-PGF2α, in infants undergoing CS and to evaluate the relationship between OS response and post-operative clinical outcomes. Infants with congenital heart disease undergoing CS with or without CPB were eligible for enrollment. Children were classified as neonates (
ISSN:	1932-6203 1932-6203
DOI:	10.1371/journal.pone.0250124