Anti-inflammatory, antibacterial and immunomodulatory treatment in children with symptoms corresponding to the research condition PANS (Pediatric Acute-onset Neuropsychiatric Syndrome): A systematic review

To assess effects of treatment against a hypothesized neuroinflammation in children with symptoms corresponding to the research condition Pediatric Acute-onset Neuropsychiatric Syndrome (PANS) which is not included in current diagnostic systems. Systematic literature searches were performed (1998 to...

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Veröffentlicht in:	PloS one 2021-07, Vol.16 (7), p.e0253844
Hauptverfasser:	Johnson, Mats, Ehlers, Stephan, Fernell, Elisabeth, Hajjari, Parisa, Wartenberg, Constanze, Wallerstedt, Susanna M
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents - administration & dosage Anti-Bacterial Agents - adverse effects Anti-Inflammatory Agents - administration & dosage Anti-Inflammatory Agents - adverse effects Anti-inflammatory drugs Antibacterial agents Antibiotics Antiinfectives and antibacterials Autoimmune Diseases - immunology Autoimmune Diseases - therapy Azithromycin Bias Biology and Life Sciences Care and treatment Child Children Clinical trials Combined Modality Therapy - adverse effects Combined Modality Therapy - methods Complications Complications and side effects Corticoids Corticosteroids Diagnostic systems Diseases disorders Glucocorticoids - administration & dosage Glucocorticoids - adverse effects Health risks Health services Hospitals Humans Immunoglobulins Immunoglobulins, Intravenous - administration & dosage Immunoglobulins, Intravenous - adverse effects Immunologic Factors - administration & dosage Immunologic Factors - adverse effects Immunomodulation Inflammation Intervention Intravenous administration intravenous immunoglobulin Literature reviews Medical research Medicine and Health Sciences Mental disorders Obsessive compulsive disorder Obsessive-Compulsive Disorder - immunology Obsessive-Compulsive Disorder - therapy Patient outcomes Patients Pediatrics Penicillin Penicillin V Plasma Exchange - adverse effects Plasma Exchange - methods Population studies prophylaxis Prostaglandin endoperoxide synthase Psychiatry Psykiatri Quality of Life R&D Randomized Controlled Trials as Topic Research & development Research and Analysis Methods Science & Technology - Other Topics Side effects Software reviews streptococcal infections Systematic review TNF inhibitors Treatment Outcome Tumor necrosis factor-TNF youth
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Beschreibung
Zusammenfassung:	To assess effects of treatment against a hypothesized neuroinflammation in children with symptoms corresponding to the research condition Pediatric Acute-onset Neuropsychiatric Syndrome (PANS) which is not included in current diagnostic systems. Systematic literature searches were performed (1998 to June 2020) in PubMed, Embase, the Cochrane Library, CINAHL, PsycInfo, and HTA databases. Inclusion criteria: patients (P) were children (
ISSN:	1932-6203 1932-6203
DOI:	10.1371/journal.pone.0253844