Thresholds of glycemia, insulin therapy, and risk for severe retinopathy in premature infants: A cohort study

Hyperglycemia in preterm infants may be associated with severe retinopathy of prematurity (ROP) and other morbidities. However, it is uncertain which concentration of blood glucose is associated with increased risk of tissue damage, with little consensus on the cutoff level to treat hyperglycemia. T...

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Veröffentlicht in:	PLoS medicine 2020-12, Vol.17 (12), p.e1003477-17
Hauptverfasser:	Kermorvant-Duchemin, Elsa, Le Meur, Guylène, Plaisant, Frank, Marchand-Martin, Laetitia, Flamant, Cyril, Porcher, Raphaël, Lapillonne, Alexandre, Chemtob, Sylvain, Claris, Olivier, Ancel, Pierre-Yves, Rozé, Jean-Christophe
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Angiogenesis Biology and Life Sciences Biomarkers - blood Birth weight Blood glucose Blood Glucose - drug effects Blood Glucose - metabolism Blood levels Care and treatment Cohort analysis Diagnosis Diseases Dosage and administration Female France Gestational Age Glucose Glycemic Control - adverse effects Glycemic index Humans Hyperglycemia Hyperglycemia - blood Hyperglycemia - complications Hyperglycemia - drug therapy Hypoglycemic Agents - adverse effects Hypoglycemic Agents - therapeutic use Infant, Newborn Infant, Premature Infants Infants (Premature) Insulin Insulin - adverse effects Insulin - therapeutic use Insulin resistance Life Sciences Male Medical examination Medicine and Health Sciences Newborn babies Parenteral nutrition People and Places Physical Sciences Premature babies Premature birth Prospective Studies Protective Factors Retinopathy Retinopathy of Prematurity - etiology Retinopathy of Prematurity - prevention & control Retrolental fibroplasia Risk Assessment Risk Factors Sensitivity analysis Sepsis Severity of Illness Index Treatment Outcome
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Zusammenfassung:	Hyperglycemia in preterm infants may be associated with severe retinopathy of prematurity (ROP) and other morbidities. However, it is uncertain which concentration of blood glucose is associated with increased risk of tissue damage, with little consensus on the cutoff level to treat hyperglycemia. The objective of our study was to examine the association between hyperglycemia and severe ROP in premature infants. In 2 independent, monocentric cohorts of preterm infants born at
ISSN:	1549-1676 1549-1277 1549-1676
DOI:	10.1371/journal.pmed.1003477