New insights into the function of mammalian Argonaute2

New insights into the function of mammalian Argonaute2

Uncovering the mechanisms that recognise a microRNA (miRNA) target is 1 of the biggest challenges because the Ago-miRNA complex is able to overcome different derogations of complementarity when binding targets. However, the recently solved crystallographic structure of Argonaute2 (Ago2) and a high-t...

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Veröffentlicht in:PLoS genetics 2020-11, Vol.16 (11), p.e1009058-e1009058
1. Verfasser: Marzec, Marek
Format: Artikel
Sprache:eng
Schlagworte:
Affinity
Algorithms
Animals
Argonaute 2 protein
Argonaute Proteins - genetics
Argonaute Proteins - metabolism
Argonaute Proteins - physiology
Binding proteins
Crystal structure
Genetic aspects
Humans
Mammals - genetics
Mammals - metabolism
MicroRNA
MicroRNAs
MicroRNAs - genetics
MicroRNAs - metabolism
miRNA
Nucleotides
Physiological aspects
Review
RNA, Guide, CRISPR-Cas Systems
RNA, Messenger - genetics
Target recognition
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Beschreibung
Zusammenfassung:Uncovering the mechanisms that recognise a microRNA (miRNA) target is 1 of the biggest challenges because the Ago-miRNA complex is able to overcome different derogations of complementarity when binding targets. However, the recently solved crystallographic structure of Argonaute2 (Ago2) and a high-throughput analysis that used repurposed sequencing techniques has brought us closer to achieving this goal.
ISSN:1553-7404
1553-7390
1553-7404
DOI:10.1371/JOURNAL.PGEN.1009058