Virologic and immunologic outcomes of treatment with integrase inhibitors in a real-world setting: The RESPOND cohort consortium

To compare virologic and immunologic outcomes of integrase inhibitor (INSTI)-containing, contemporary boosted protease inhibitor (PI/b)-containing and non-nucleotide reverse transcriptase inhibitor (NNRTI)-containing regimens in a real-life setting. Using logistic regression, virologic and immunolog...

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Veröffentlicht in:	PloS one 2020-12, Vol.15 (12), p.e0243625-e0243625
Hauptverfasser:	Neesgaard, Bastian, Mocroft, Amanda, Zangerle, Robert, Wit, Ferdinand, Lampe, Fiona, Günthard, Huldrych F, Necsoi, Coca, Law, Matthew, Mussini, Cristina, Castagna, Antonella, Monforte, Antonella d'Arminio, Pradier, Christian, Chkhartisvilli, Nikoloz, Reyes-Uruena, Juliana, Vehreschild, Jörg Janne, Wasmuth, Jan-Christian, Sönnerborg, Anders, Stephan, Christoph, Greenberg, Lauren, Llibre, Josep M, Volny-Anne, Alain, Peters, Lars, Pelchen-Matthews, Annegret, Vannappagari, Vani, Gallant, Joel, Rieger, Armin, Youle, Mike, Braun, Dominique, De Wit, Stephane, Petoumenos, Kathy, Borghi, Vanni, Spagnuolo, Vincenzo, Tsertsvadze, Tengiz, Lundgren, Jens, Ryom, Lene
Format:	Artikel
Sprache:	eng
Schlagworte:	Acquired immune deficiency syndrome Adult AIDS Antiretroviral agents Antiretroviral drugs Antiretroviral therapy Biology and Life Sciences Care and treatment CD4 antigen CD4 Lymphocyte Count Cohort Studies Confidence intervals Consortia Diabetes Epidemiology Female HIV HIV - drug effects HIV - immunology HIV infection HIV Infections - drug therapy HIV Infections - immunology HIV Infections - virology HIV Integrase Inhibitors - therapeutic use HIV Protease Inhibitors - therapeutic use Hospitals Human immunodeficiency virus Humans Immunology Infectious diseases Integrase Integrase inhibitors Male Medicine and Health Sciences Middle Aged Non-nucleoside reverse transcriptase inhibitors Nucleotides Patient outcomes People and Places Protease inhibitors Proteinase inhibitors Regression analysis Reverse Transcriptase Inhibitors - therapeutic use RNA-directed DNA polymerase Sensitivity analysis Statistical analysis Testing Treatment Outcome Viral Load - drug effects Viral Load - immunology Virology Windows (intervals) World population
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Beschreibung
Zusammenfassung:	To compare virologic and immunologic outcomes of integrase inhibitor (INSTI)-containing, contemporary boosted protease inhibitor (PI/b)-containing and non-nucleotide reverse transcriptase inhibitor (NNRTI)-containing regimens in a real-life setting. Using logistic regression, virologic and immunologic outcomes of INSTI use were compared to outcomes of PI/b or NNRTI treatment 12 months after treatment start or switch, for participants in the RESPOND cohort consortium. A composite treatment outcome (cTO) was used, defining success as viral load (VL)
ISSN:	1932-6203 1932-6203
DOI:	10.1371/journal.pone.0243625