Variant analysis of 1,040 SARS-CoV-2 genomes

Variant analysis of 1,040 SARS-CoV-2 genomes

The severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) viral genome is an RNA virus consisting of approximately 30,000 bases. As part of testing efforts, whole genome sequencing of human isolates has resulted in over 1,600 complete genomes publicly available from GenBank. We have performed...

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Veröffentlicht in:PloS one 2020-11, Vol.15 (11), p.e0241535-e0241535
Hauptverfasser: Rouchka, Eric C, Chariker, Julia H, Chung, Donghoon
Format: Artikel
Sprache:eng
Schlagworte:
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Betacoronavirus - genetics
Bioinformatics
Biology and life sciences
Biomedical research
Comparative analysis
Control
Coronaviruses
COVID-19
Disease transmission
Epidemics
Gene mutation
Gene sequencing
Genetic aspects
Genetic Linkage
Genome, Viral
Genomes
Genotypes
Glycoproteins
Identification and classification
Linkage Disequilibrium
Lod Score
Medicine and health sciences
Mutation
Phylogenetics
Properties
Proteins
Research and Analysis Methods
RNA polymerase
RNA viruses
SARS-CoV-2
Seafood
Seafoods
Sequence Analysis, RNA
Severe acute respiratory syndrome
Severe acute respiratory syndrome coronavirus 2
United States
Viral diseases
Viruses
Whole Genome Sequencing
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Beschreibung
Zusammenfassung:The severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) viral genome is an RNA virus consisting of approximately 30,000 bases. As part of testing efforts, whole genome sequencing of human isolates has resulted in over 1,600 complete genomes publicly available from GenBank. We have performed a comparative analysis of the sequences, in order to detect common mutations within the population. Analysis of variants occurring within the assembled genomes yields 417 variants occurring in at least 1% of the completed genomes, including 229 within the 5' untranslated region (UTR), 152 within the 3'UTR, 2 within intergenic regions and 34 within coding sequences.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0241535