Utilizing methylglyoxal and D-lactate in urine to evaluate saikosaponin C treatment in mice with accelerated nephrotoxic serum nephritis

The relationship between methylglyoxal (MGO) and D-lactate during saikosaponin C (SSC) treatment of mice with accelerated nephrotoxic serum (NTS) nephritis was investigated. NTS nephritis was induced by administration of anti-basement membrane antibodies to C57BL/6 mice and three dosages of SSC were...

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Veröffentlicht in:	PloS one 2020-10, Vol.15 (10), p.e0241053
Hauptverfasser:	Lin, Chia-Yu, Lee, Jen-Ai, Lin, Po-Yeh, Hua, Shih-Chun, Tsai, Pei-Yun, Chen, Bi-Li, Lin, Chia-En, Lee, Tzong-Huei, Chen, Shih-Ming
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies Antigens Biology and Life Sciences Care and treatment Chromatography Creatinine Dehydrogenases Dosage Glomerulonephritis - drug therapy Health aspects Histology Hypertrophy Immunoglobulins Ketones Kidneys Laboratory animals Lactates Lactic acid Lactic Acid - urine Medicine and Health Sciences Membranes Metabolism Metabolites Mice Mice, Inbred C57BL Monocytes Nephritis Oleanolic Acid - administration & dosage Oleanolic Acid - analogs & derivatives Oleanolic Acid - therapeutic use Pharmacy Physiological aspects Proteins Proteinuria Pyruvaldehyde Pyruvaldehyde - urine Rabbits Saponins Saponins - administration & dosage Saponins - therapeutic use Supervision Urea Urine
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Zusammenfassung:	The relationship between methylglyoxal (MGO) and D-lactate during saikosaponin C (SSC) treatment of mice with accelerated nephrotoxic serum (NTS) nephritis was investigated. NTS nephritis was induced by administration of anti-basement membrane antibodies to C57BL/6 mice and three dosages of SSC were administered for 14 days. Proteinuria, blood urea nitrogen, serum creatinine, renal histology, urinary MGO and d-lactate changes were examined. Compared to the NTS control group, the middle dosage (10 mg/kg/day) of SSC significantly alleviated the development of nephritis based on urine protein measurements (34.40 ± 6.85 vs. 17.33 ± 4.79 mg/day, p
ISSN:	1932-6203 1932-6203
DOI:	10.1371/journal.pone.0241053