Characterization of adult patients with IgG subclass deficiency and subnormal IgG2

Adults with IgG subclass deficiency (IgGSD) with subnormal IgG2 are inadequately characterized. We retrospectively analyzed observations in unrelated adults with IgGSD evaluated in a single hematology clinic (1991-2019) and selected those with subnormal serum IgG2 (

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Bibliographische Detailangaben
Veröffentlicht in:	PloS one 2020-10, Vol.15 (10), p.e0240522-e0240522
Hauptverfasser:	Barton, James C, Barton, Jackson C, Bertoli, Luigi F, Acton, Ronald T
Format:	Artikel
Sprache:	eng
Schlagworte:	Abnormalities Adult Adults Allergies Antibiotics Antigens Atopy Autoimmune diseases Biology and Life Sciences Biomarkers - blood Corticosteroids Demographic aspects Diagnosis Female Follow-Up Studies Haplotypes Hematology Histocompatibility antigen HLA HLA Antigens - metabolism Humans Hypersensitivity IgG Deficiency - blood IgG Deficiency - epidemiology IgG Deficiency - pathology Immunoglobulin A Immunoglobulin G Immunoglobulin G - blood Immunoglobulin M Immunoglobulins Immunologic deficiency syndromes Incidence Infections Laboratories Leukocytes Lymphocytes Lymphocytes - metabolism Lymphocytes - pathology Male Measurement Medical records Medicine and Health Sciences Middle Aged Patients Polysaccharides Prognosis Respiratory tract Respiratory tract diseases Respiratory Tract Infections - blood Respiratory Tract Infections - epidemiology Respiratory Tract Infections - pathology Retrospective Studies Risk Factors ROC Curve Standard deviation Subpopulations Vaccination Vitamin E
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Beschreibung
Zusammenfassung:	Adults with IgG subclass deficiency (IgGSD) with subnormal IgG2 are inadequately characterized. We retrospectively analyzed observations in unrelated adults with IgGSD evaluated in a single hematology clinic (1991-2019) and selected those with subnormal serum IgG2 (
ISSN:	1932-6203 1932-6203
DOI:	10.1371/journal.pone.0240522