Fasting plasma glucose level and the risk of open angle glaucoma: Nationwide population-based cohort study in Korea

The level of fasting plasma glucose (FPG) is positively associated with intraocular pressure. Diabetes causes early structural changes of retina, especially on ganglion cell layer. In this regard, the FPG level itself may also show an independent association with open angle glaucoma (OAG) development in general population. Herein, we investigate the association of the FPG level with the incidence of OAG. Using nationally representative data from the Korean National Health Insurance System, 374,376 subjects [greater than or equal to]40 years of age without OAG who underwent health examinations from 2009 to 2013 were enrolled and followed to the end of 2014. Incident cases of OAG using the International Classification of Diseases 10 codes and medication information were analyzed based on the levels of FPG. Subjects with the highest FPG level ([greater than or equal to]160 mg/dL), compared with the lowest level (