Early effect of laser irradiation in signaling pathways of diabetic rat submandibular salivary glands

Low-power laser irradiation (LPLI) is clinically used to modulate inflammation, proliferation and apoptosis. However, its molecular mechanisms are still not fully understood. This study aimed to describe the effects of LPLI upon inflammatory, apoptotic and proliferation markers in submandibular sali...

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Veröffentlicht in:	PloS one 2020-08, Vol.15 (8), p.e0236727-e0236727
Hauptverfasser:	Fukuoka, Cíntia Yuki, Vicari, Hugo Passos, Sipert, Carla Renata, Bhawal, Ujjal Kumar, Abiko, Yoshimitsu, Arana-Chavez, Victor Elias, Simões, Alyne
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies Apoptosis Autophagy Bax protein Biochemistry Biology and Life Sciences Biomedical materials Care and treatment Cell survival Cellular signal transduction Cyclic AMP - metabolism Cyclic AMP response element-binding protein Cyclic AMP Response Element-Binding Protein - metabolism Dentistry Diabetes Diabetes mellitus Diabetes Mellitus, Experimental - radiotherapy Engineering and Technology Female Growth factors Health aspects HMGB1 protein HMGB1 Protein - genetics HMGB1 Protein - metabolism Homeostasis Inflammation Irradiation Laboratory animals Laser therapy Lasers Low-Level Light Therapy Markers Medicine and Health Sciences Metabolism Methods Mitochondria Mitogen-Activated Protein Kinases - metabolism Molecular biology Molecular modelling NF-kappa B - metabolism Phosphorylation Proteins Rats Rats, Wistar Research and Analysis Methods RNA, Messenger - metabolism Salivary gland Salivary glands Signal Transduction - radiation effects Streptozocin Submandibular Gland - radiation effects Supervision Transcription activation Tumor Necrosis Factor-alpha - metabolism Tumor necrosis factor-TNF Tumor necrosis factor-α
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Zusammenfassung:	Low-power laser irradiation (LPLI) is clinically used to modulate inflammation, proliferation and apoptosis. However, its molecular mechanisms are still not fully understood. This study aimed to describe the effects of LPLI upon inflammatory, apoptotic and proliferation markers in submandibular salivary glands (SMGs) in an experimental model of chronic disorder, 24h after one time irradiation. Diabetes was induced in rats by the injection of streptozotocin. After 29 days, these animals were treated with LPLI in the SMG area, and euthanized 24h after this irradiation. Treatment with LPLI significantly decreased diabetes-induced high mobility group box 1 (HMGB1) and tumor necrosis factor alpha (TNF-α) expression, while enhancing the activation of the transcriptional factor cAMP response element binding (CREB) protein. LPLI also reduced the expression of bax, a mitochondrial apoptotic marker, favoring the cell survival. These findings suggest that LPLI can hamper the state of chronic inflammation and favor homeostasis in diabetic rats SMGs.
ISSN:	1932-6203 1932-6203
DOI:	10.1371/journal.pone.0236727