Biological sex impacts COVID-19 outcomes

The current novel coronavirus disease 2019 (COVID-19) pandemic is revealing profound differences between men and women in disease outcomes worldwide. In the United States, there has been inconsistent reporting and analyses of male-female differences in COVID-19 cases, hospitalizations, and deaths. W...

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Veröffentlicht in:PLoS pathogens 2020-06, Vol.16 (6), p.e1008570-e1008570
Hauptverfasser: Klein, Sabra L, Dhakal, Santosh, Ursin, Rebecca L, Deshpande, Sharvari, Sandberg, Kathryn, Mauvais-Jarvis, Franck
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Sprache:eng
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Zusammenfassung:The current novel coronavirus disease 2019 (COVID-19) pandemic is revealing profound differences between men and women in disease outcomes worldwide. In the United States, there has been inconsistent reporting and analyses of male-female differences in COVID-19 cases, hospitalizations, and deaths. We seek to raise awareness about the male-biased severe outcomes from COVID-19, highlighting the mechanistic differences including in the expression and activity of angiotensin-converting enzyme 2 (ACE2) as well as in antiviral immunity. We also highlight how sex differences in comorbidities, which can be associated with both age and race, impact male-biased outcomes from COVID-19.
ISSN:1553-7374
1553-7366
1553-7374
DOI:10.1371/journal.ppat.1008570