Plasma cytokine profiles in very preterm infants with late-onset sepsis

Deficiencies in innate immune responses may contribute to the increased susceptibility to infection in preterm infants. In vivo cytokine profiles in response to sepsis in very preterm infants are not fully understood. To characterise plasma pro- and anti-inflammatory cytokine concentrations and pre-...

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Veröffentlicht in:	PloS one 2020-05, Vol.15 (5), p.e0232933
Hauptverfasser:	Hibbert, Julie, Strunk, Tobias, Simmer, Karen, Richmond, Peter, Burgner, David, Currie, Andrew
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-inflammatory agents Antibiotics Bacterial infections Biology and Life Sciences Correlation analysis Cytokines Demographic aspects Diagnosis Disease susceptibility Education Gestational age Health aspects IL-1β Immune response Immunoassay Infants Infection Infections Inflammation Inflammatory response Innate immunity Interleukin 10 Interleukin 12 Interleukin 15 Interleukin 6 Interleukin 8 IP-10 protein Longitudinal studies Medical schools Medicine and Health Sciences Monocyte chemoattractant protein 1 Mortality Newborn babies People and Places Peripheral blood Plasma Premature babies Premature infants Sepsis Statistical analysis Studies Time Tumor necrosis factor-α γ-Interferon
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Zusammenfassung:	Deficiencies in innate immune responses may contribute to the increased susceptibility to infection in preterm infants. In vivo cytokine profiles in response to sepsis in very preterm infants are not fully understood. To characterise plasma pro- and anti-inflammatory cytokine concentrations and pre-defined ratios in very preterm infants with late-onset sepsis (LOS). In this observational study, peripheral blood samples were collected at the time of evaluation for suspected LOS from 31 preterm infants (
ISSN:	1932-6203 1932-6203
DOI:	10.1371/journal.pone.0232933