Effect of short-term prednisone on beta-cell function in subjects with type 2 diabetes mellitus and healthy subjects

Effect of short-term prednisone on beta-cell function in subjects with type 2 diabetes mellitus and healthy subjects

For those with type 2 diabetes mellitus (T2DM), impact of short-term high-dose glucocorticoid exposure on beta-cell function is unknown. This study aims to compare the impact on beta-cell function and insulin resistance of prednisone 40 mg between adults with newly diagnosed T2DM and healthy adults....

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Veröffentlicht in:PloS one 2020-05, Vol.15 (5), p.e0231190-e0231190
Hauptverfasser: Shah, Monica, Adel, May M, Tahsin, Bettina, Guerra, Yannis, Fogelfeld, Leon
Format: Artikel
Sprache:eng
Schlagworte:
Adults
Beta cells
Biology and Life Sciences
Diabetes
Diabetes mellitus
Diabetes mellitus (non-insulin dependent)
Diabetes therapy
Exposure
Fasting
Fragility
Glucocorticoids
Glucose
Glucose tolerance
Glycosylated hemoglobin
Hemoglobin
Homeostasis
Hyperglycemia
Insulin
Insulin resistance
Insulin secretion
Medicine and Health Sciences
Metformin
Pancreatic beta cells
Peptides
Physical Sciences
Prednisone
Sample size
Shift work
Short term
Studies
Therapy
Type 2 diabetes
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Zusammenfassung:For those with type 2 diabetes mellitus (T2DM), impact of short-term high-dose glucocorticoid exposure on beta-cell function is unknown. This study aims to compare the impact on beta-cell function and insulin resistance of prednisone 40 mg between adults with newly diagnosed T2DM and healthy adults. Five adults with T2DM and five healthy adults, all between 18-50 years, were enrolled. T2DM diagnosis was less than one year prior, HbA1c
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0231190