Prevalence of chronic chikungunya and associated risks factors in the French West Indies (La Martinique): A prospective cohort study

The chikungunya virus (CHIKV) is a re-emerging alphavirus that can cause chronic and potentially incapacitating rheumatic musculoskeletal disorders known as chronic chikungunya arthritis (CCA). We conducted a prospective cohort study of CHIKV-infected subjects during the 2013 chikungunya outbreak in...

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Veröffentlicht in:	PLoS neglected tropical diseases 2020-03, Vol.14 (3), p.e0007327-e0007327
Hauptverfasser:	Bertolotti, Antoine, Thioune, Marême, Abel, Sylvie, Belrose, Gilda, Calmont, Isabelle, Césaire, Raymond, Cervantes, Minerva, Fagour, Laurence, Javelle, Émilie, Lebris, Catherine, Najioullah, Fatiha, Pierre-François, Sandrine, Rozé, Benoît, Vigan, Marie, Laouénan, Cédric, Cabié, André
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Arthritis Arthritis - epidemiology Arthritis - pathology Biology and life sciences Chikungunya fever Chikungunya Fever - epidemiology Chikungunya Fever - pathology Chikungunya virus Chikungunya virus - classification Chikungunya virus - genetics Chikungunya virus - isolation & purification Chronic Disease Cohort analysis Cohorts Dehydration Disorders DNA Dyspnea Edema Epidemics Female Females Fever Follow-Up Studies Genotype Genotypes Headache Headaches Hospitals Human health and pathology Humans Infections Infectious diseases Intravenous administration Life Sciences Male Martinique - epidemiology Medicine and Health Sciences Microbiology and Parasitology Middle Aged Musculoskeletal diseases Nucleic acids Nucleotide sequence Pain PCR Population Prevalence Prognosis Prospective Studies Quality of life Questionnaires Real-Time Polymerase Chain Reaction Regression analysis Regression models Rehydration Respiration Reverse Transcriptase Polymerase Chain Reaction Rhumatology and musculoskeletal system Ribonucleic acid Risk analysis Risk Factors RNA RNA, Viral - genetics RNA, Viral - isolation & purification Santé publique et épidémiologie Sex Statistics Tenosynovitis Tropical diseases Urea Vector-borne diseases Vertigo Virology Viruses Vomiting Working groups Young Adult
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Zusammenfassung:	The chikungunya virus (CHIKV) is a re-emerging alphavirus that can cause chronic and potentially incapacitating rheumatic musculoskeletal disorders known as chronic chikungunya arthritis (CCA). We conducted a prospective cohort study of CHIKV-infected subjects during the 2013 chikungunya outbreak in Martinique. The aim of this study was to assess the prevalence of CCA at 12 months and to search for acute phase factors significantly associated with chronicity. A total of 193 patients who tested positive for CHIKV RNA via qRT-PCR underwent clinical investigations in the acute phase (
ISSN:	1935-2735 1935-2727 1935-2735
DOI:	10.1371/journal.pntd.0007327