Rad51 paralogs and the risk of unselected breast cancer: A case-control study

A case-control study was conducted in which we evaluated the association between genetic variability of DNA repair proteins belonging to the Rad51 family and breast cancer (BrC) risk. In the study, 132 female BrC cases and 189 healthy control females were genotyped for a total of 14 common single nu...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	PloS one 2020-01, Vol.15 (1), p.e0226976
Hauptverfasser:	Gresner, Peter, Jablonska, Ewa, Gromadzinska, Jolanta
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Biology and Life Sciences Breast cancer Breast Neoplasms - genetics Cancer research Cancer therapies Case-Control Studies Chromosomes Computer and Information Sciences Deoxyribonucleic acid DNA DNA damage DNA repair DNA-Binding Proteins - genetics Epistasis, Genetic Female Females Gene expression Genes Genetic polymorphisms Genetic Predisposition to Disease Genetic testing Genetic variability Genome-Wide Association Study Genotype Genotypes Haplotypes Health aspects Health risks Humans Learning algorithms Machine Learning Medicine Medicine and Health Sciences Middle Aged Mutation Nucleotides Ovarian cancer Polymorphism, Single Nucleotide Proteins Rad51 Recombinase - genetics RecA protein Risk Risk Assessment Risk factors Single nucleotide polymorphisms Single-nucleotide polymorphism Studies
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	A case-control study was conducted in which we evaluated the association between genetic variability of DNA repair proteins belonging to the Rad51 family and breast cancer (BrC) risk. In the study, 132 female BrC cases and 189 healthy control females were genotyped for a total of 14 common single nucleotide polymorphisms (SNPs) within Rad51 and Xrcc3. Moreover, our previously reported Rad51C genetic data were involved to explore the nonlinear interactions among SNPs within the three genes and effect of such interactions on BrC risk. The rare rs5030789 genotype (-4601AA) in Rad51 was found to significantly decrease the BrC risk (OR = 0.5, 95% CI: 0.3-1.0, p
ISSN:	1932-6203 1932-6203
DOI:	10.1371/journal.pone.0226976