Effectiveness of four types of neuraminidase inhibitors approved in Japan for the treatment of influenza

Neuraminidase inhibitors (NAIs) effectively treat influenza. The clinical effectiveness of four NAIs (oseltamivir, zanamivir, laninamivir, and peramivir) was evaluated against influenza A/H1N1pdm09, A/H3N2, and B viruses. Additionally, fever duration in patients infected with oseltamivir-resistant i...

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Veröffentlicht in:	PloS one 2019-11, Vol.14 (11), p.e0224683-e0224683
Hauptverfasser:	Mawatari, Momoko, Saito, Reiko, Hibino, Akinobu, Kondo, Hiroki, Yagami, Ren, Odagiri, Takashi, Tanabe, Ikumi, Shobugawa, Yugo
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Ambulatory care facilities Analysis Biology and Life Sciences Body temperature Child Child, Preschool Clinics Collaboration Drug Approval Drug dosages Drug therapy Enzyme Inhibitors - therapeutic use Exo-a-sialidase Fever Fever - complications Humans Illnesses Infant Infant, Newborn Infections Influenza Influenza A Influenza A Virus, H1N1 Subtype - genetics Influenza B Influenza, Human - complications Influenza, Human - drug therapy Informed consent Inhibitors Japan Laninamivir Medicine and Health Sciences Multivariate Analysis Mutation Mutation - genetics Neuraminidase - antagonists & inhibitors Oseltamivir Oseltamivir - therapeutic use Oseltamivir phosphate Outpatient care facilities Pandemics Patients People and Places Peramivir Polymerase chain reaction Proportional Hazards Models Public health Seasons Temperature Treatment Outcome Viruses Young Adult Zanamivir
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Zusammenfassung:	Neuraminidase inhibitors (NAIs) effectively treat influenza. The clinical effectiveness of four NAIs (oseltamivir, zanamivir, laninamivir, and peramivir) was evaluated against influenza A/H1N1pdm09, A/H3N2, and B viruses. Additionally, fever duration in patients infected with oseltamivir-resistant influenza A/H1N1pdm09 with the H275Y mutation was evaluated. Patients aged
ISSN:	1932-6203 1932-6203
DOI:	10.1371/journal.pone.0224683