Unexpected high seroprevalence of hepatitis E virus in patients with alcohol-related cirrhosis

Little is known about hepatitis E virus (HEV) infection in patients with cirrhosis. The aim of the present study was to describe the frequency of HEV infection and associated risk factors in patients with cirrhosis from Argentina. We evaluated HEV seroprevalence (IgG anti-HEV) and acute infections (...

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Veröffentlicht in:PloS one 2019-10, Vol.14 (10), p.e0224404
Hauptverfasser: Fantilli, Anabella C, Trinks, Julieta, Marciano, Sebastián, Zárate, Fabián, Balderramo, Domingo C, Wassaf, Maribel G Martínez, Haddad, Leila, Gadano, Adrián, Debes, José D, Pisano, María B, Ré, Viviana E
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Sprache:eng
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Zusammenfassung:Little is known about hepatitis E virus (HEV) infection in patients with cirrhosis. The aim of the present study was to describe the frequency of HEV infection and associated risk factors in patients with cirrhosis from Argentina. We evaluated HEV seroprevalence (IgG anti-HEV) and acute infections (IgM and RNA) in patients with cirrhosis (n = 140) vs. healthy controls (n = 300). Additionally, we compared the same outcomes in individuals with alcohol-related cirrhosis (n = 43) vs. patients with alcohol use disorder (without cirrhosis, n = 72). The overall HEV seroprevalence in the cohort of subjects with cirrhosis was 25% (35/140), compared to 4% in the healthy control group [12/300; OR = 8; (95% CI = 4-15.99); p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0224404