Switching to bedaquiline for treatment of rifampicin-resistant tuberculosis in South Africa: A retrospective cohort analysis

South Africa led the world with guidelines on bedaquiline (BDQ) use as a single drug substitution to manage rifampin resistant tuberculosis regimen toxicity. We examined reasons for giving BDQ in a retrospective cohort: >75% of patients were switched to BDQ for toxicity (ototoxicity or renal dysf...

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Veröffentlicht in:	PloS one 2019-10, Vol.14 (10), p.e0223308-e0223308
Hauptverfasser:	Bouton, Tara C, de Vos, Margaretha, Ragan, Elizabeth J, White, Laura F, Van Zyl, Leonie, Theron, Danie, Horsburgh, C Robert, Warren, Robin M, Jacobson, Karen R
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Antitubercular Agents - therapeutic use Biology and Life Sciences Clinical outcomes Cohort analysis Coinfection Diarylquinolines - administration & dosage Diarylquinolines - therapeutic use Drug resistance Drug Substitution Drug Therapy, Combination Female Health sciences HIV Infections Hospitals Humans Infectious diseases Male Medical research Medicine Medicine and Health Sciences Meta-analysis Middle Aged Molecular biology Multidrug resistant organisms Mycobacterium tuberculosis - drug effects Ototoxicity Patients Public health Renal function Retreatment Retrospective Studies Rifampin Rifampin - therapeutic use South Africa Systematic review Toxicity Treatment Outcome Tuberculosis Tuberculosis, Multidrug-Resistant - diagnosis Tuberculosis, Multidrug-Resistant - drug therapy Tuberculosis, Multidrug-Resistant - microbiology
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Zusammenfassung:	South Africa led the world with guidelines on bedaquiline (BDQ) use as a single drug substitution to manage rifampin resistant tuberculosis regimen toxicity. We examined reasons for giving BDQ in a retrospective cohort: >75% of patients were switched to BDQ for toxicity (ototoxicity or renal dysfunction) rather than drug resistance.
ISSN:	1932-6203 1932-6203
DOI:	10.1371/journal.pone.0223308