Schistosoma mansoni soluble egg antigen (SEA) and recombinant Omega-1 modulate induced CD4+ T-lymphocyte responses and HIV-1 infection in vitro

Parasitic helminths evade, skew and dampen human immune responses through numerous mechanisms. Such effects will likely have consequences for HIV-1 transmission and disease progression. Here we analyzed the effects that soluble egg antigen (SEA) from Schistosoma mansoni had on modulating HIV-1 infec...

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Veröffentlicht in:	PLoS pathogens 2019-09, Vol.15 (9), p.e1007924-e1007924
Hauptverfasser:	Mouser, Emily Eim, Pollakis, Georgios, Smits, Hermelijn H, Thomas, Jordan, Yazdanbakhsh, Maria, de Jong, Esther C, Paxton, William A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Helminth - immunology Antibodies, Helminth - metabolism Antigens Antigens, Helminth - immunology Antigens, Helminth - metabolism Biology and Life Sciences CCR5 protein CD4 antigen CD4-Positive T-Lymphocytes - immunology Cell culture Cell surface Chemokines Cytokines - metabolism Cytomegalovirus DC-SIGN protein Dendritic cells Dendritic Cells - immunology Dendritic Cells - metabolism Disease transmission Egg Proteins - immunology Egg Proteins - metabolism Eggs Exposure Gene expression Glycoproteins HIV HIV Infections - immunology HIV Infections - metabolism HIV Infections - prevention & control HIV-1 - immunology Human behavior Human immunodeficiency virus Humans Immune system Immunology Infections Infectivity Laboratories Lymphocyte Activation Lymphocytes Lymphocytes T Medicine and Health Sciences Parasites Parasitology Populations Receptors, CCR5 - metabolism Research and Analysis Methods Schistosoma mansoni Schistosoma mansoni - metabolism Soluble egg antigen Supervision T-Lymphocytes, Helper-Inducer - immunology Viral infections Virology Virus Replication - immunology Viruses γ-Interferon
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Beschreibung
Zusammenfassung:	Parasitic helminths evade, skew and dampen human immune responses through numerous mechanisms. Such effects will likely have consequences for HIV-1 transmission and disease progression. Here we analyzed the effects that soluble egg antigen (SEA) from Schistosoma mansoni had on modulating HIV-1 infection and cytokine/chemokine production in vitro. We determined that SEA, specifically through kappa-5, can potently bind to DC-SIGN and thereby blocks DC-SIGN mediated HIV-1 trans-infection (p
ISSN:	1553-7374 1553-7366 1553-7374
DOI:	10.1371/journal.ppat.1007924