Using graph learning to understand adverse pregnancy outcomes and stress pathways

To identify pathways between stress indicators and adverse pregnancy outcomes, we applied a nonparametric graph-learning algorithm, PC-KCI, to data from an observational prospective cohort study. The Measurement of Maternal Stress study (MOMS) followed 744 women with a singleton intrauterine pregnan...

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Veröffentlicht in:	PloS one 2019-09, Vol.14 (9), p.e0223319-e0223319
Hauptverfasser:	Mesner, Octavio, Davis, Alex, Casman, Elizabeth, Simhan, Hyagriv, Shalizi, Cosma, Keenan-Devlin, Lauren, Borders, Ann, Krishnamurti, Tamar
Format:	Artikel
Sprache:	eng
Schlagworte:	Abortion, Spontaneous - diagnosis Abortion, Spontaneous - epidemiology Abortion, Spontaneous - metabolism Adult Algorithms Analysis Anxiety Biology and Life Sciences Biomarkers - metabolism Birth Childhood Children Cortisol Data collection Data mining Delivery, Obstetric Diabetes mellitus Diabetes, Gestational - diagnosis Diabetes, Gestational - epidemiology Diabetes, Gestational - metabolism Eclampsia Engineering Female Generalized linear models Gestation Gestational Age Gestational diabetes Gestational hypertension Glucocorticoids Graph theory Gynecology Hair Hair - chemistry Hair - metabolism Health aspects Humans Hydrocortisone - metabolism Hypertension Hypertension, Pregnancy-Induced - diagnosis Hypertension, Pregnancy-Induced - epidemiology Hypertension, Pregnancy-Induced - metabolism Infant, Low Birth Weight Infant, Newborn Infant, Premature Live Birth Machine learning Maternal & child health Mediation Medicine and Health Sciences Membranes Obstetrics People and Places Pre-eclampsia Pre-Eclampsia - diagnosis Pre-Eclampsia - epidemiology Pre-Eclampsia - metabolism Preeclampsia Pregnancy Pregnancy complications Pregnant women Premature birth Premature rupture of the membrane Prospective Studies Proteins Psychological aspects Public policy Race Researchers Risk factors Small for gestational age Social interactions Social Sciences Statistics, Nonparametric Stillbirth Stress Stress (Psychology) Stress, Psychological - diagnosis Stress, Psychological - epidemiology Stress, Psychological - metabolism Studies Systematic review Trauma United States - epidemiology Variables Weight Women Womens health
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Zusammenfassung:	To identify pathways between stress indicators and adverse pregnancy outcomes, we applied a nonparametric graph-learning algorithm, PC-KCI, to data from an observational prospective cohort study. The Measurement of Maternal Stress study (MOMS) followed 744 women with a singleton intrauterine pregnancy recruited between June 2013 and May 2015. Infant adverse pregnancy outcomes were prematurity (
ISSN:	1932-6203 1932-6203
DOI:	10.1371/journal.pone.0223319