Inclusion of key populations in clinical trials of new antituberculosis treatments: Current barriers and recommendations for pregnant and lactating women, children, and HIV-infected persons

Amita Gupta and colleagues discuss priorities in clinical research aimed at improving tuberculosis prevention and treatment in pregnant women, children, and people with HIV.

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Bibliographische Detailangaben
Veröffentlicht in:	PLoS medicine 2019-08, Vol.16 (8), p.e1002882
Hauptverfasser:	Gupta, Amita, Hughes, Michael D, Garcia-Prats, Anthony J, McIntire, Katherine, Hesseling, Anneke C
Format:	Artikel
Sprache:	eng
Schlagworte:	Acquired immune deficiency syndrome Adults AIDS Analysis Antitubercular agents Antitubercular Agents - therapeutic use Biology and Life Sciences Care and treatment CD4 antigen Child Children Children & youth Childrens health Clinical outcomes Clinical trials Clinical Trials as Topic - methods Coinfection - microbiology Coinfection - virology Collection Review Disease control Disease prevention Drug dosages Drug therapy Evidence-based medicine Female Fetuses Formulations Health aspects Health sciences HIV HIV infections HIV Infections - complications Homeless people Human immunodeficiency virus Humans Infections Infectious diseases Lactation Medical treatment Medicine Medicine and Health Sciences Patient Selection People and Places Pregnancy Pregnancy Complications, Infectious - drug therapy Pregnant women Pyrazinamide Research and Analysis Methods Sputum Teenagers Therapeutics Tuberculosis Tuberculosis, Pulmonary - complications Tuberculosis, Pulmonary - drug therapy Tutu, Desmond Womens health
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Beschreibung
Zusammenfassung:	Amita Gupta and colleagues discuss priorities in clinical research aimed at improving tuberculosis prevention and treatment in pregnant women, children, and people with HIV.
ISSN:	1549-1676 1549-1277 1549-1676
DOI:	10.1371/journal.pmed.1002882