Desmoplasia and oncogene driven acinar-to-ductal metaplasia are concurrent events during acinar cell-derived pancreatic cancer initiation in young adult mice

The five-year survival rate of patients diagnosed with advanced pancreatic ductal adenocarcinoma (PDAC) has remained static at

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Bibliographische Detailangaben
Veröffentlicht in:	PloS one 2019-09, Vol.14 (9), p.e0221810
Hauptverfasser:	Johnson, Benjamin L, d'Alincourt Salazar, Marcela, Mackenzie-Dyck, Sarah, D'Apuzzo, Massimo, Shih, Hung Ping, Manuel, Edwin R, Diamond, Don J
Format:	Artikel
Sprache:	eng
Schlagworte:	Acinar cells Acinar Cells - pathology Adenocarcinoma Alleles Animal models Animals Biology and Life Sciences Cancer Cancer research Carcinogenesis - genetics Carcinogenesis - pathology Carcinogens Carcinoma Carcinoma, Pancreatic Ductal - genetics Carcinoma, Pancreatic Ductal - pathology Care and treatment Cell differentiation Cell survival Clinical trials Cre recombinase Deposition Development and progression Diagnosis Disease Progression Erlotinib Estrogen receptors Estrogens Extracellular matrix Fibrosis Fusion protein Gastroenterology Gene expression Gene Expression Profiling Genetic aspects Genetic engineering Genetically modified organisms Hematology Hyaluronic acid Invasiveness Laboratory animals Latency Lesions Liver Liver cancer Medicine and Health Sciences Menopause Metaplasia Metaplasia - genetics Metaplasia - pathology Metastasis Mice Motility Mutation Oncogenes Oncogenes - genetics Pancreas - pathology Pancreatic cancer Pancreatic carcinoma Pancreatitis Physical Sciences Proto-Oncogene Proteins p21(ras) - genetics Recombinase Research and Analysis Methods Rodents Survival Tamoxifen Tumor Suppressor Protein p53 - genetics Tumorigenesis Tumors Young adults Youth
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Beschreibung
Zusammenfassung:	The five-year survival rate of patients diagnosed with advanced pancreatic ductal adenocarcinoma (PDAC) has remained static at
ISSN:	1932-6203 1932-6203
DOI:	10.1371/journal.pone.0221810