Dosage form suitability in vulnerable populations: A focus on paracetamol acceptability from infants to centenarians

Medicine acceptability is a multi-faceted concept driven by both product and user characteristics. Although a key factor for treatment effectiveness, especially in vulnerable populations, knowledge of those medicine features that best promote individual user acceptability remains fragmented. Focusin...

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Veröffentlicht in:	PloS one 2019-08, Vol.14 (8), p.e0221261-e0221261
Hauptverfasser:	Ruiz, Fabrice, Vallet, Thibault, Dufaÿ Wojcicki, Amélie, Belissa, Émilie, Fontan, Jean-Eudes, de Pontual, Loïc, Nathanson, Sylvie, Chevallier, Alain, Laribe-Caget, Sandra, Boudy, Vincent
Format:	Artikel
Sprache:	eng
Schlagworte:	Acceptability Acetaminophen Acetaminophen - administration & dosage Administration, Oral Adolescent Age Factors Aged Aged, 80 and over Aging Analgesics Analysis Biology and Life Sciences Centenarians Child Child, Preschool Clustering Data analysis Descriptive labeling Disintegration Dosage Dosage and administration Dosage Forms Dose-response relationship Drug dosages Female Formulations Galenic pharmacology Geriatrics Health aspects Hospitals Humans Infant Infant, Newborn Infants Innovations Life Sciences Local population Mapping Medication Adherence Medicine Medicine and Health Sciences Methods Nursing homes Older people Oldest old people Paracetamol Patients Pediatrics People and Places Pharmaceutical sciences Pharmaceuticals Pharmacology Physical Sciences Population Populations Powder Product development Prospective Studies Swallowing Tablets Vulnerable Populations
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Beschreibung
Zusammenfassung:	Medicine acceptability is a multi-faceted concept driven by both product and user characteristics. Although a key factor for treatment effectiveness, especially in vulnerable populations, knowledge of those medicine features that best promote individual user acceptability remains fragmented. Focusing on paracetamol, this study has explored the appropriateness of pharmaceutical products in different dosage forms to achieve adequate patient acceptability from infants to centenarians. This observational, multicentre, prospective study was carried out in 10 hospitals, 8 nursing homes and over 150 community dispensaries. Observers reported several behaviours/events evaluating acceptability for 1016 different pharmaceutical product uses in paediatrics (
ISSN:	1932-6203 1932-6203
DOI:	10.1371/journal.pone.0221261