Early identification of acute kidney injury in Russell's viper (Daboia russelii) envenoming using renal biomarkers

Acute kidney injury (AKI) is a major complication of snake envenoming, but early diagnosis remains problematic. We aimed to investigate the time course of novel renal biomarkers in AKI following Russell's viper (Daboia russelii) bites. We recruited a cohort of patients with definite Russell...

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Veröffentlicht in:	PLoS neglected tropical diseases 2019-07, Vol.13 (7), p.e0007486
Hauptverfasser:	Ratnayake, Indira, Mohamed, Fahim, Buckley, Nicholas A, Gawarammana, Indika B, Dissanayake, Dhammika M, Chathuranga, Umesh, Munasinghe, Mahesh, Maduwage, Kalana, Jayamanne, Shaluka, Endre, Zoltan H, Isbister, Geoffrey K
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Kidney Injury - blood Acute Kidney Injury - diagnosis Acute Kidney Injury - etiology Acute Kidney Injury - urine Adolescent Adult Aged Albumin Animals Biochemistry Bioindicators Biological markers Biology and Life Sciences Biomarkers Biomarkers - blood Biomarkers - urine Biomedical materials Bites Bites (Injuries) Care and treatment Clusterin Cohorts Collaboration Complications and side effects Creatinine Cystatin C Daboia Daboia russelii Development and progression Enzymes Female Gelatinase Gene expression Health aspects Humans Identification Identification and classification Immunoassay Injuries Kidney diseases Kidneys Laboratories Lipocalin Male Medicine Medicine and Health Sciences Middle Aged Nephrology Neurotoxicity Neutrophils Osteopontin Predictions Prospective Studies Risk Assessment Serum Snake bites Snake Bites - complications Snakes Time Factors Toxicology Trefoil factor Tropical diseases Urine Venom Viper Venoms - blood Viper Venoms - urine Vipers Wounds Young Adult β2 Microglobulin
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Beschreibung
Zusammenfassung:	Acute kidney injury (AKI) is a major complication of snake envenoming, but early diagnosis remains problematic. We aimed to investigate the time course of novel renal biomarkers in AKI following Russell's viper (Daboia russelii) bites. We recruited a cohort of patients with definite Russell's viper envenoming and collected serial blood and urine samples on admission (
ISSN:	1935-2735 1935-2727 1935-2735
DOI:	10.1371/journal.pntd.0007486