Enteric infection and dysfunction-A new target for PLOS Neglected Tropical Diseases

GH resistance, defined by elevated systemic GH levels and low levels of insulin-like growth factor 1 (IGF-1; the hormone principally responsible for stimulating local bone and tissue growth), is exhibited in states of caloric and protein undernutrition, isolated micronutrient deficiencies (zinc, vit...

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Veröffentlicht in:PLoS neglected tropical diseases 2018-12, Vol.12 (12), p.e0006906-e0006906
Hauptverfasser: Arndt, Michael B, Walson, Judd L
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Sprache:eng
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Zusammenfassung:GH resistance, defined by elevated systemic GH levels and low levels of insulin-like growth factor 1 (IGF-1; the hormone principally responsible for stimulating local bone and tissue growth), is exhibited in states of caloric and protein undernutrition, isolated micronutrient deficiencies (zinc, vitamin A, magnesium), and in response to chronic systemic inflammation [12–16]. PLOS Neglected Tropical Diseases is uniquely positioned to highlight research addressing these gaps from basic research to the implementation of interventions at scale. Because the etiology and physiology of enteric dysfunction is incompletely defined, it is essential that model systems (e.g., animal models, organoids, in vitro cell models) be developed to elucidate some of the underlying features of the condition. [...]these invasive procedures may not be practical or ethical to utilize among children in low-resource settings. Because several forms of enteric dysfunction are often coendemic in low-resource settings, it is critical to harmonize case definitions to ensure proper classification of similar clinical entities from differing etiologies, because the etiology is likely relevant for elicitation of response to a given treatment approach. A study in 3-to-9-month-old Gambian infants also did not observe a reduction in lactulose excretion or intestinal inflammation (fecal calprotectin levels) in children supplemented with long-chain polyunsaturated fatty acids (fish oil) [37].
ISSN:1935-2735
1935-2727
1935-2735
DOI:10.1371/journal.pntd.0006906