Risk of spontaneous preterm birth and fetal growth associates with fetal SLIT2

Spontaneous preterm birth (SPTB) is the leading cause of neonatal death and morbidity worldwide. Both maternal and fetal genetic factors likely contribute to SPTB. We performed a genome-wide association study (GWAS) on a population of Finnish origin that included 247 infants with SPTB (gestational a...

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Veröffentlicht in:	PLoS genetics 2019-06, Vol.15 (6), p.e1008107-e1008107
Hauptverfasser:	Tiensuu, Heli, Haapalainen, Antti M, Karjalainen, Minna K, Pasanen, Anu, Huusko, Johanna M, Marttila, Riitta, Ojaniemi, Marja, Muglia, Louis J, Hallman, Mikko, Rämet, Mika
Format:	Artikel
Sprache:	eng
Schlagworte:	Acids Axon guidance Biology and Life Sciences Birth Birth weight Children & youth Collaboration Cytokines Death Decidua Embryos Female Fetal development Fetal Development - genetics Fetus Fetuses Finland Gene expression Gene Expression Regulation - genetics Gene Frequency Gene regulation Genes Genetic aspects Genetic factors Genetic Predisposition to Disease Genetic research Genome-wide association studies Genome-Wide Association Study Genomes Genomics Gestational age Hospitals Humans Immunohistochemistry Infant mortality Infants Inflammation Intercellular Signaling Peptides and Proteins - genetics Medical research Medicine and Health Sciences Messenger RNA Morbidity mRNA Neonates Nerve Tissue Proteins - genetics Newborn infants Pediatrics Placenta Placenta - pathology Polymorphism, Single Nucleotide Population studies Pregnancy Pregnancy-Specific beta 1-Glycoproteins - genetics Premature birth Premature Birth - genetics Premature Birth - pathology Premature infants Prevention Receptors, Immunologic - genetics Risk factors RNA Roundabout Proteins Signal Transduction siRNA Slit protein Software Studies Supervision Teenagers Trophoblasts Trophoblasts - pathology Visualization Working groups
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Zusammenfassung:	Spontaneous preterm birth (SPTB) is the leading cause of neonatal death and morbidity worldwide. Both maternal and fetal genetic factors likely contribute to SPTB. We performed a genome-wide association study (GWAS) on a population of Finnish origin that included 247 infants with SPTB (gestational age [GA] < 36 weeks) and 419 term controls (GA 38-41 weeks). The strongest signal came within the gene encoding slit guidance ligand 2 (SLIT2; rs116461311, minor allele frequency 0.05, p = 1.6×10-6). Pathway analysis revealed the top-ranking pathway was axon guidance, which includes SLIT2. In 172 very preterm-born infants (GA
ISSN:	1553-7404 1553-7390 1553-7404
DOI:	10.1371/journal.pgen.1008107