Discovery of a dual protease mechanism that promotes DNA damage checkpoint recovery

The DNA damage response is a signaling pathway found throughout biology. In many bacteria the DNA damage checkpoint is enforced by inducing expression of a small, membrane bound inhibitor that delays cell division providing time to repair damaged chromosomes. How cells promote checkpoint recovery af...

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Veröffentlicht in:	PLoS genetics 2018-07, Vol.14 (7), p.e1007512-e1007512
Hauptverfasser:	Burby, Peter E, Simmons, Zackary W, Schroeder, Jeremy W, Simmons, Lyle A
Format:	Artikel
Sprache:	eng
Schlagworte:	Bacillus subtilis - physiology Bacteria Bacterial Proteins - genetics Bacterial Proteins - metabolism Bacteriology Biology and Life Sciences Cell cycle Cell Cycle Checkpoints - genetics Cell division Cell proliferation Chromosomes Clonal deletion Deoxyribonucleic acid Developmental biology DNA DNA damage DNA Damage - physiology DNA repair DNA Repair - physiology DNA Transposable Elements - genetics DNA, Bacterial - genetics E coli Endopeptidases - genetics Endopeptidases - metabolism Genes Genetic aspects Genetic research Genetic screening Genomes Kinases Medicine and Health Sciences Membrane Proteins - genetics Membrane Proteins - metabolism Mutation Physiological aspects Proteases Proteinase Proteins Proteomics Research and Analysis Methods Signal transduction
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