Gene-edited babies: What went wrong and what could go wrong

During the second World Summit of Human Gene Editing, Jiankui He presented the gene-editing project that led to the birth of two baby girls with man-made C-C chemokine receptor type 5 (CCR5) mutations. This extremely irresponsible behavior violated the ethical consensus of scientists all over the wo...

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Veröffentlicht in:PLoS biology 2019-04, Vol.17 (4), p.e3000224-e3000224
Hauptverfasser: Wang, Haoyi, Yang, Hui
Format: Artikel
Sprache:eng
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Zusammenfassung:During the second World Summit of Human Gene Editing, Jiankui He presented the gene-editing project that led to the birth of two baby girls with man-made C-C chemokine receptor type 5 (CCR5) mutations. This extremely irresponsible behavior violated the ethical consensus of scientists all over the world. His presentation revealed a troubling lack not only of basic medical ethics but also of the requisite understanding of genetics and gene editing. Here, we review the rationale and design of his experiment along with the presented data, and provide our scientific criticism of this misconduct.
ISSN:1545-7885
1544-9173
1545-7885
DOI:10.1371/journal.pbio.3000224