Involvement of Elf3 on Smad3 activation-dependent injuries in podocytes and excretion of urinary exosome in diabetic nephropathy

Diabetic nephropathy (DN) is among the most serious complications of diabetes mellitus, and often leads to end-stage renal disease ultimately requiring dialysis or renal transplantation. The loss of podocytes has been reported to have a role in the onset and progression of DN. Here, we addressed the...

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Veröffentlicht in:	PloS one 2019-05, Vol.14 (5), p.e0216788-e0216788
Hauptverfasser:	Sakurai, Akiko, Ono, Hiroyuki, Ochi, Arisa, Matsuura, Motokazu, Yoshimoto, Sakiya, Kishi, Seiji, Murakami, Taichi, Tominaga, Tatsuya, Nagai, Kojiro, Abe, Hideharu, Doi, Toshio
Format:	Artikel
Sprache:	eng
Schlagworte:	Activation Age Animals Biology and Life Sciences Biomarkers - urine Bone morphogenetic protein 4 Complications Diabetes Diabetes mellitus Diabetic Nephropathies - pathology Diabetic Nephropathies - urine Diabetic nephropathy Dialysis DNA-Binding Proteins - urine End-stage renal disease Epidermal growth factor receptors Epithelium Excretion Exosomes Exosomes - metabolism Exosomes - pathology Glomerular Filtration Rate Hyperglycemia Injuries Injury prevention Kidney diseases Kidney transplantation Kinases Male Medicine and Health Sciences Mice Nephrology Nephropathy Podocytes - metabolism Podocytes - pathology Proteins Research and Analysis Methods Secretion Signal Transduction Signaling Smad3 protein Smad3 Protein - urine Transcription factors Transcription Factors - urine Transplantation University graduates Urine
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