Involvement of Elf3 on Smad3 activation-dependent injuries in podocytes and excretion of urinary exosome in diabetic nephropathy

Diabetic nephropathy (DN) is among the most serious complications of diabetes mellitus, and often leads to end-stage renal disease ultimately requiring dialysis or renal transplantation. The loss of podocytes has been reported to have a role in the onset and progression of DN. Here, we addressed the...

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Veröffentlicht in:	PloS one 2019-05, Vol.14 (5), p.e0216788-e0216788
Hauptverfasser:	Sakurai, Akiko, Ono, Hiroyuki, Ochi, Arisa, Matsuura, Motokazu, Yoshimoto, Sakiya, Kishi, Seiji, Murakami, Taichi, Tominaga, Tatsuya, Nagai, Kojiro, Abe, Hideharu, Doi, Toshio
Format:	Artikel
Sprache:	eng
Schlagworte:	Activation Age Animals Biology and Life Sciences Biomarkers - urine Bone morphogenetic protein 4 Complications Diabetes Diabetes mellitus Diabetic Nephropathies - pathology Diabetic Nephropathies - urine Diabetic nephropathy Dialysis DNA-Binding Proteins - urine End-stage renal disease Epidermal growth factor receptors Epithelium Excretion Exosomes Exosomes - metabolism Exosomes - pathology Glomerular Filtration Rate Hyperglycemia Injuries Injury prevention Kidney diseases Kidney transplantation Kinases Male Medicine and Health Sciences Mice Nephrology Nephropathy Podocytes - metabolism Podocytes - pathology Proteins Research and Analysis Methods Secretion Signal Transduction Signaling Smad3 protein Smad3 Protein - urine Transcription factors Transcription Factors - urine Transplantation University graduates Urine
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Zusammenfassung:	Diabetic nephropathy (DN) is among the most serious complications of diabetes mellitus, and often leads to end-stage renal disease ultimately requiring dialysis or renal transplantation. The loss of podocytes has been reported to have a role in the onset and progression of DN. Here, we addressed the activation mechanism of Smad3 signaling in podocytes. Expression of RII and activation of Smad3 were induced by AGE exposure (P
ISSN:	1932-6203 1932-6203
DOI:	10.1371/journal.pone.0216788